Endocrine Abstracts

Background: Few previous studies suggested a negative impact of obesity on anti-Mullerian hormone (AMH) serum levels in patients with decreased ovarian reserve, but the data regarding the relationship between AMH and adiposity in the same category of patients without severe excess of body weight are scarce.Aim: The aim of the study was to evaluate the relationship between AMH serum levels and BMI in normal weight and overweight patients with reduced ovar...

It was suggested that polycystic ovary syndrome (PCOS) patients have an increased risk for autoimmune thyroid disease. However the mechanisms underlying this association are incompletely clarified. The aim of the present study is to evaluate the factors associated with thyroid autoimmunity in patients with PCOS. We performed a retrospective study which included 126 PCOS patients (mean age 24±4.5 years, mean body mass index, BMI 27±7.33 kg/sqm) diagnosed based on Rott...

Introduction: Opioids are commonly used for the treatment of pain, and their effects on the HPA (hypothalamic pituitary adrenal) axis may be under-recognised. In the present, a few non-systematic studies have investigated the effects of opioids on the HPA axis, but results have been conflicting. To our knowledge, there is only another case report of secondary adrenal insufficiency due to tramadol therapy, resulted in suppression on the HPA axis. We present the case of a 79 yea...

Infertility affects milions of couples worldwide. Determining the exact cause represents a real challenge and may require a complex work-up.Objective: To asses the main etiological factors of female infertility and the best treatment.Methods: Retrospective study which included 150 women diagnosed with infertility in a Romanian tertiary center. The median age was 30.5 years (20–41), 65.3% (n=98) of the patients were di...

IntroductionGrowth hormone deficiency (GHD) is a rare disorder and severe forms of GHD may have a genetic basis. Familial isolated growth hormone deficiency (IGHD) is classified into 4 types, type IA being the most severe form. These patients present with severe growth failure with undetectable growth hormone (GH) concentrations and about 50% tend to develop antibodies on GH treatment.(1, 2, 3) The appearance of anti-GH antibodies may not be a regular fi...

Affecting multiple aspects of every-day living, Covid-19 could be a stress-promoting event, and short-stature patients could be an at-risk population. The scope of our study is to assess whether the on-going pandemic could affect children’s response to growth hormone therapy. This was a retrospective study that evaluated children on growth hormone treatment who presented for clinical visits between September 2019 and January 2021 at the Pediatric Endocrinology Department ...

IntroductionBoth vitamin D insufficiency and multinodular goiter (MNG) are widespread throughout the world, with Romanian population being no exception. However, at this point in time there is insufficient data whether there is a connection between the two or is it just a coincidence. The aim of this study is to evaluate whether there is a relationship between serum level of 25-hydroxyvitamin D (25OHD) and the risk of differentiated thyroid cancer (DTC) ...

Congenital adrenal hyperplasia (CAH) is a group of diseases which develop as a result of deficient enzymes or co-factor proteins required for cortisol biosynthesis. Depending on the defect, the manifestations range from life-threatening salt-wasting syndrome to almost no symptoms. Nevertheless, some subclinical subtypes can cause impediments in particular situations. This case brings to light a possible manifestation of CAH, revealed in the process of in-vitro fertilization. W...

Background: PCOS patients associate an increased risk of glucose metabolism abnormalities. Although Hb A1c was suggested as a good diagnostic test for prediabetes/diabetes, in PCOS patients its diagnostic value could be inferior to OGTT as previously suggested. Aim of the study was to evaluate which are the clinical and paraclinical parameters associated with impaired glucose tolerance (IGT) in order to identify the profile of the patients that will benefit from OGTT.<p cl...

Beta-thalssaemia major (BTM) is a rare disease that encompasses a vast range of endocrinological complications, despite of the improvement of treatment protocols. The aim of this study was to identify the clinical and hematological parameters associated with osteoporosis, a frequent complication found in beta-thalassaemia patients.Patients with BTM were evaluated in the Endocrinology Department of Elias Hospital between February 2004 and March 2016. Only...